Description

Boc-(2R,3S)-2-Amino-3-Hydroxy-4-Methylpentanoic Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a stereochemically defined (2R,3S) configuration. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over molecular structure and biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for oncology, metabolic, and infectious disease targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a constrained, β-hydroxy amino acid motif, influencing peptide backbone conformation and stability.
• Protease Inhibitor Development: Acts as a core structural component in the design of selective enzyme inhibitors, leveraging its hydroxymethyl side chain for targeted molecular interactions.
• Bioconjugation & Labeling: The Boc-protected amine provides a handle for selective deprotection and subsequent conjugation with fluorescent dyes, affinity tags, or other functional molecules.
• Chemical Biology Research: Employed in the study of protein-protein interactions and signal transduction pathways by incorporating non-natural amino acids into model peptides.
• Material Science: Potential use in creating functionalized polymers or surfaces with specific chiral recognition properties for separation technologies.

Basic Information

Product Name	Boc-(2R,3S)-2-Amino-3-Hydroxy-4-Methylpentanoic Acid
CAS No.	102507-17-5
Molecular Formula	C11H21NO5
Molecular Weight	247.29 g/mol
Synonyms	(2R,3S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxy-4-methylpentanoic acid; Boc-Threonine(4-Me) isomer; (2R,3S)-3-Hydroxy-2-((tert-butoxycarbonyl)amino)-4-methylpentanoic acid; N-Boc-3-hydroxy-4-methyl-L-threonine; N-(tert-Butoxycarbonyl)-3-hydroxy-4-methyl-L-threonine; Boc-4-methylthreonine; (2R,3S)-2-(Boc-amino)-3-hydroxy-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our Boc-(2R,3S)-2-Amino-3-Hydroxy-4-Methylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity (HPLC), specific rotation, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.