Description

Quinonoid-(6R)-Dihydro-L-Biopterin Hydrochloride is a high-purity, chemically defined derivative of the essential cofactor tetrahydrobiopterin (BH4). This compound matters as a critical reference standard and synthetic intermediate for research and development in enzymology and metabolic studies. It is primarily needed by pharmaceutical R&D teams, diagnostic manufacturers, and academic researchers focusing on nitric oxide synthases, aromatic amino acid hydroxylases, and related biochemical pathways.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, MS) in drug development and quality control.
• Enzyme Research: Serves as a substrate or inhibitor in studies of pterin-dependent enzymes like phenylalanine-4-hydroxylase (PAH).
• Diagnostic Reagent Manufacturing: A key component in the formulation of test kits for inborn errors of metabolism, such as hyperphenylalaninemia.
• Biochemical Synthesis: Acts as a crucial synthetic building block for the preparation of other biologically active pterin derivatives and labeled analogs.
• Cell Culture & Neuroscience Research: Investigated for its role in neurotransmitter synthesis and cellular redox signaling pathways.

Basic Information

Product Name	Quinonoid-(6R)-Dihydro-L-Biopterin Hydrochloride
CAS No.	102340-67-0
Molecular Formula	C9H15N5O3 • HCl
Molecular Weight	293.71 g/mol (Free base: 257.25 g/mol)
Synonyms	6R-Quinonoid Dihydro-L-Biopterin HCl; (6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin Quinonoid Dihydro Isomer Hydrochloride; 6R-BH2 Quinonoid HCl; 6R-Q-BH2 HCl; Quinonoid-6R-Dihydrobiopterin Hydrochloride; 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one Quinonoid Dihydro Isomer Hydrochloride
EINECS	Contact for details

Quality Control

Our Quinonoid-(6R)-Dihydro-L-Biopterin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and MS, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.