Description

D-Alanine, 3,3,3-Trifluoro-2-Methyl- (9Ci) is a high-value, non-natural amino acid derivative characterized by its unique trifluoromethyl group and D-configuration. This compound is a critical chiral building block in advanced organic synthesis, offering enhanced metabolic stability and lipophilicity to target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated pharmaceuticals, including protease inhibitors and other bioactive molecules.
• Agrochemical Research: Used in the synthesis of novel, fluorinated pesticides and herbicides, where the trifluoromethyl group can improve activity and environmental persistence.
• Peptide Chemistry: Incorporated into custom peptides to study structure-activity relationships (SAR), enhance stability against enzymatic degradation, and modulate physicochemical properties.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals, where fluorine substitution imparts unique thermal and chemical resistance.
• Chemical Biology Probes: Utilized in the design of molecular probes and labeled compounds for metabolic pathway studies and imaging applications.
• Asymmetric Synthesis Catalyst Ligand: Can be used to derive chiral ligands or auxiliaries for enantioselective catalytic reactions.

Basic Information

Item	Detail
Product Name	D-Alanine, 3,3,3-Trifluoro-2-Methyl- (9Ci)
CAS No.	102210-03-7
Molecular Formula	C4H6F3NO2
Molecular Weight	157.09 g/mol
Synonyms	(2R)-2-Amino-3,3,3-trifluoro-2-methylpropanoic acid; D-3,3,3-Trifluoro-2-methylalanine; (R)-3,3,3-Trifluoro-2-methylalanine; D-α-(Trifluoromethyl)alanine; (R)-2-Amino-3,3,3-trifluoro-2-methylpropionic acid; 3,3,3-Trifluoro-D-2-methylalanine; 102210-03-7; D-TfmAla
EINECS	Contact for details

Quality Control

Our D-Alanine, 3,3,3-Trifluoro-2-Methyl- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkali and fluoride ions; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.