Description

Boc-Dl-Tle-Oh is a protected amino acid derivative widely used in peptide synthesis and pharmaceutical research. This compound is essential for introducing the sterically hindered tert-leucine residue into peptide chains, which can significantly influence the conformational stability and biological activity of the final product. It serves as a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of tert-leucine during automated peptide assembly.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing complex peptide sequences in solution.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of active pharmaceutical ingredients (APIs), especially for peptide-based drugs.
• Bioconjugation and Labeling: The Boc-protected carboxylic acid group allows for selective conjugation to other molecules, useful in creating probes or drug conjugates.
• Peptidomimetic Design: Employed to create non-natural peptide analogs with enhanced metabolic stability, bioavailability, or receptor selectivity.
• Academic and Industrial Research: A standard reagent in chemistry and biochemistry laboratories for studying protein structure-function relationships and developing new synthetic methodologies.

Basic Information

Product Name	Boc-Dl-Tle-Oh
CAS No.	102185-35-3
Molecular Formula	C₁₁H₂₁NO₄
Molecular Weight	231.29 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-DL-tert-leucine; Boc-DL-tert-Leucine; (RS)-2-[(tert-Butoxycarbonyl)amino]-3,3-dimethylbutanoic acid; DL-N-Boc-tert-leucine; Boc-DL-Tle-OH; tert-Butyloxycarbonyl-DL-tert-leucine; 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3,3-dimethylbutanoic acid; N-Boc-DL-tert-leucine
EINECS	Contact for details

Quality Control

Our Boc-Dl-Tle-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.