Description

Boc-D-Pro-Osu CAS NO 102185-34-2 is a high-purity, protected amino acid derivative, specifically the N-Boc-protected D-Proline active ester. This compound matters as a critical chiral building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of the non-natural D-proline isomer into peptide chains. Pharmaceutical researchers and fine chemical manufacturers need it for the development of therapeutic peptides, peptidomimetics, and other bioactive molecules where stereochemistry and purity are paramount for efficacy and safety.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated synthesis of complex peptides containing D-proline residues.
• Pharmaceutical Intermediates: Used in the research and production of peptide-based drugs targeting GPCRs, enzymes, and other biological pathways.
• Peptidomimetic Design: Essential for creating stable, protease-resistant analogs of natural peptides for enhanced drug properties.
• Bioconjugation: Facilitates the site-specific labeling or functionalization of peptides and proteins.
• Academic & Industrial R&D: Employed in medicinal chemistry and chemical biology research for exploring structure-activity relationships (SAR).
• Custom Peptide Services: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Boc-D-Pro-Osu
CAS No.	102185-34-2
Molecular Formula	C15H22N2O6
Molecular Weight	326.35 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-proline N-hydroxysuccinimide ester; Boc-D-proline-OSu; 1-[(2,5-Dioxopyrrolidin-1-yl)oxy]-1-oxo-5-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (D-form); (R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)oxy)succinimidyl pyrrolidine-1-carboxylate; tert-Butyl (2R)-2-[(2,5-dioxopyrrolidin-1-yl)oxycarbonyl]pyrrolidine-1-carboxylate; Boc-D-Pro-OSu; N-Boc-D-proline succinimidyl ester; D-Boc-Pro-OSu
EINECS	Contact for details

Quality Control

Our Boc-D-Pro-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research and cGMP manufacturing applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.