Description

Ibudilast-D3 (Major) is a deuterated isotopologue of the phosphodiesterase (PDE) inhibitor Ibudilast, specifically designed for use as an internal standard in analytical chemistry. This compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers requiring precise and stable isotope-labeled reference materials for LC-MS/MS and GC-MS applications.

Application

• Internal Standard for Bioanalysis: Primary use as a stable isotope-labeled internal standard for the accurate quantification of Ibudilast in biological matrices (plasma, serum, urine) via LC-MS/MS.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies, enabling precise measurement of drug concentration and absorption rates.
• Clinical Trial Support: Ensures data integrity in clinical bioanalytical testing for studies involving Ibudilast or related compounds.
• Metabolite Identification: Aids in the identification and quantification of drug metabolites in complex biological samples.
• Method Development & Validation: Critical component for developing, validating, and transferring robust analytical methods in compliance with GLP/GCP guidelines.
• Quality Control in Manufacturing: Can be utilized in in-process testing and final product release assays for Ibudilast-based pharmaceutical formulations.

Basic Information

Product Name	Ibudilast-D3 (Major)
CAS No.	102064-45-9
Molecular Formula	C14H15D3N2O
Molecular Weight	233.32 g/mol (approx.)
Synonyms	3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine-D3; KC-404-d3; AV-411-d3; MN-166-d3; Ibudilast (deuterated, major isotopologue); 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone-D3
EINECS	Contact for details

Quality Control

Our Ibudilast-D3 (Major) is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We adhere to industry best practices, and our quality commitment supports compliance in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 98.0 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.