Description

Na-Benzyl-L-Histidine Methyl Ester Dihydrochloride is a protected derivative of the essential amino acid L-Histidine, specifically designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over the histidine side chain during complex coupling reactions. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating the benzyl-protected histidine residue into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling methodologies for the production of custom peptides and small protein fragments.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Biochemical Research: Employed in studies of protein structure-function relationships, enzyme mechanisms, and receptor-ligand interactions.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Protecting Group Strategy: The Na-benzyl group allows for selective deprotection under specific conditions, enabling complex multi-step syntheses.

Basic Information

Product Name	Na-Benzyl-L-Histidine Methyl Ester Dihydrochloride
CAS No.	102029-99-2
Molecular Formula	C14H20N4O2 · 2HCl
Molecular Weight	357.26 g/mol (as free base, contact for salt form weight)
Synonyms	L-Histidine, N-α-benzyl-, methyl ester, dihydrochloride; Nα-Benzyl-L-histidine methyl ester dihydrochloride; Methyl Nα-benzyl-L-histidinate dihydrochloride; Benzyl-L-histidine methyl ester HCl; (S)-Methyl 2-(benzylamino)-3-(1H-imidazol-4-yl)propanoate dihydrochloride; Na-Bzl-His-OMe · 2HCl; Protected L-Histidine derivative
EINECS	Contact for details

Quality Control

Our Na-Benzyl-L-Histidine Methyl Ester Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.