Description

Sar-Arg-Val-Tyr-Ile-His-Pro-Phe is a synthetic peptide fragment, also known as Saralasin Acetate, which acts as a competitive angiotensin II receptor antagonist. This compound is of significant interest in biochemical and pharmacological research for studying the renin-angiotensin system and related cardiovascular pathways. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in cardiovascular disease research, peptide chemistry, and drug discovery programs.

Application

• Biochemical Research: Used as a specific tool compound to study angiotensin II receptor (AT1) binding and signal transduction mechanisms.
• Pharmacological Studies: Serves as a reference standard in assays for screening and characterizing new antihypertensive agents or receptor modulators.
• Cardiovascular Research: Employed in experimental models to investigate hypertension, vascular tone regulation, and cardiac function.
• Peptide Synthesis Reference: Acts as a building block or a comparative standard in the development and quality control of synthetic peptide APIs.
• Academic & Institutional Research: Fundamental research tool in university and institutional labs focusing on endocrinology and peptide hormone action.

Basic Information

Product Name	Sar-Arg-Val-Tyr-Ile-His-Pro-Phe
CAS No.	102029-89-0
Molecular Formula	C₄₉H₆₉N₁₅O₁₀
Molecular Weight	1044.2 g/mol
Synonyms	Saralasin; Saralasin Acetate; [Sar¹,Ala⁸]Angiotensin II; 1-Sarcosine-8-alanine-angiotensin II; N-Sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Angiotensin II Antagonist; UNII-4X6E73C6OQ
EINECS	Contact for details

Quality Control

Our Sar-Arg-Val-Tyr-Ile-His-Pro-Phe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	5.0% - 12.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.