Description

Desamido-Neuropeptide Y is a synthetic peptide analog of the endogenous neurotransmitter Neuropeptide Y (NPY), specifically lacking the C-terminal amide group. This modification makes it a valuable research tool for studying NPY receptor interactions and signaling pathways in the central and peripheral nervous systems. It is essential for biochemical research, pharmaceutical development, and academic studies focused on metabolism, appetite regulation, and cardiovascular function.

Application

• Neuroscience Research: Used as a reference standard and receptor ligand in studies investigating NPY receptor subtypes (Y1, Y2, Y4, Y5, Y6).
• Pharmacological Studies: Employed in competitive binding assays and functional studies to characterize novel NPY receptor agonists and antagonists.
• Metabolic Disorder Research: A key tool for exploring the role of NPY in appetite control, energy homeostasis, and obesity-related pathways.
• Cardiovascular Research: Applied in studies examining NPY's effects on blood pressure, heart rate, and vascular tone.
• Biochemical Standard: Serves as a high-purity standard for analytical method development and validation in peptide analysis.
• Drug Discovery: Used in high-throughput screening (HTS) campaigns to identify and optimize new therapeutic candidates targeting NPY receptors.

Basic Information

Product Name	Desamido-Neuropeptide Y
CAS No.	101994-11-0
Molecular Formula	C190H287N55O57S2
Molecular Weight	4252.7 g/mol
Synonyms	Desamido-NPY; NPY (free acid); Neuropeptide Y (desamido); [Desamido]-Neuropeptide Y; Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2 (Free Acid); H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-OH
EINECS	Contact for details

Quality Control

Our Desamido-Neuropeptide Y is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.