Description

3'-(Difluoromethoxy)Acetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoromethoxy group can impart desirable metabolic stability and bioavailability. Pharmaceutical R&D teams and fine chemical manufacturers need this high-purity intermediate to facilitate the efficient synthesis of novel therapeutic candidates and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethoxy moiety enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance display technologies.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and structure-activity relationships.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP or non-GMP production of client-specific target molecules.

Basic Information

Product Name	3'-(Difluoromethoxy)Acetophenone
CAS No.	101975-23-9
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	1-[3-(Difluoromethoxy)phenyl]ethanone; 3-(Difluoromethoxy)acetophenone; 3-Acetyldifluoromethoxybenzene; 3-Difluoromethoxyacetophenone; m-(Difluoromethoxy)acetophenone; Ethanone, 1-[3-(difluoromethoxy)phenyl]-; 3'-Difluoromethoxyacetophenone
EINECS	Contact for details

Quality Control

Our 3'-(Difluoromethoxy)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards required for pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.