Description

1-[4-(Difluoromethoxy)-3-Methoxyphenyl]Ethan-1-One is a high-purity, specialized aromatic ketone building block featuring a difluoromethoxy functional group, which is critical for modulating the physicochemical properties of advanced molecules. This compound is valued for its role as a key intermediate in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms can significantly enhance metabolic stability and bioavailability. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to develop novel compounds with optimized performance profiles.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated motifs for improved efficacy and ADMET properties.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoromethoxy group can contribute to enhanced biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a precursor in the development of fluorinated organic electronic materials for displays and lighting applications.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of client-specific, high-value fine chemicals and complex organic molecules.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, particularly in cross-coupling and fluorination chemistry research.

Basic Information

Product Name	1-[4-(Difluoromethoxy)-3-Methoxyphenyl]Ethan-1-One
CAS No.	101975-20-6
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	1-(4-(Difluoromethoxy)-3-methoxyphenyl)ethanone; 4'-Difluoromethoxy-3'-methoxyacetophenone; 1-[4-(Difluoromethoxy)-3-methoxyphenyl]ethanone; 4-(Difluoromethoxy)-3-methoxyacetophenone; Ethanone, 1-[4-(difluoromethoxy)-3-methoxyphenyl]-; 3-Methoxy-4-(difluoromethoxy)acetophenone; DFMA
EINECS	Contact for details

Quality Control

Our 1-[4-(Difluoromethoxy)-3-Methoxyphenyl]Ethan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.