Description

Proinsulin, Des-(23-63)- is a specific, truncated form of proinsulin, a key precursor in insulin biosynthesis. This high-purity intermediate is critical for advanced research into insulin processing, secretion, and the development of novel therapeutic strategies for diabetes. It serves as an essential reference standard and starting material for biopharmaceutical R&D, particularly in metabolic disease studies and peptide hormone analysis.

Application

• Biochemical Research: Used as a critical reference standard and substrate in studies of prohormone convertase activity, insulin maturation pathways, and protein folding.
• Pharmaceutical Development: Serves as a key intermediate and analytical standard in the research and development of novel insulin analogs and diabetes therapeutics.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays designed to measure proinsulin and its related peptides in clinical samples.
• Metabolic Disease Studies: Essential for investigating β-cell function, insulin secretion mechanisms, and the pathophysiology of type 1 and type 2 diabetes.
• Peptide Chemistry & Synthesis: Acts as a model compound for studying disulfide bond formation, peptide stability, and large-scale peptide synthesis techniques.
• Quality Control & Regulatory Compliance: Provides a certified reference material for ensuring the purity and identity of insulin-related products in GMP manufacturing environments.

Basic Information

Item	Detail
Product Name	Proinsulin, Des-(23-63)-
CAS No.	101962-68-9
Molecular Formula	C254H377N65O76S6
Molecular Weight	5808.5 g/mol (approx.)
Synonyms	Des(23-63)-Proinsulin; Human Proinsulin (23-63) Des; Proinsulin (1-22)-(64-86); Proinsulin Intermediate; Truncated Proinsulin; Insulin Precursor Fragment; BIOT-00072; Proinsulin Des B23-C63
EINECS	Contact for details

Quality Control

Our Proinsulin, Des-(23-63)- is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to a comprehensive battery of analytical tests, including HPLC for purity, mass spectrometry for identity confirmation, and bioactivity assays. A detailed Certificate of Analysis (COA) documenting purity, endotoxin levels, and full analytical data is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Biological Activity	Assessed by specific binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.