Description

Desmethyl Butenafine Hydrochloride is a key pharmaceutical intermediate and reference standard of significant importance in antifungal research and development. This compound is valued for its role in the synthesis and quality control of butenafine, a potent allylamine antifungal agent. It is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in developing and testing topical antifungal formulations.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of the active pharmaceutical ingredient (API) Butenafine Hydrochloride.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing of butenafine-based products.
• Biochemical Research: Employed in pharmacological studies to investigate the structure-activity relationship (SAR) and mechanism of action of allylamine antifungals.
• Impurity Profiling: Serves as a specified impurity standard for monitoring and controlling the quality of butenafine API during manufacturing.
• Antifungal Agent Development: Utilized in R&D for creating novel derivative compounds with potential enhanced efficacy or altered pharmacokinetic profiles.

Basic Information

Product Name	Desmethyl Butenafine Hydrochloride
CAS No.	101828-08-4
Molecular Formula	C22H27N·HCl
Molecular Weight	333.92 g/mol
Synonyms	N-[(4-tert-Butylphenyl)methyl]-N-methyl-1-naphthalenemethanamine Hydrochloride; Butenafine Desmethyl Impurity; Butenafine Related Compound A; (4-tert-Butylbenzyl)methyl(1-naphthylmethyl)amine Hydrochloride; Desmethylbutenafine HCl; Des-Butenafine Hydrochloride; Butenafine EP Impurity A; Butenafine USP Impurity A
EINECS	Contact for details

Quality Control

Our Desmethyl Butenafine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets stringent specifications for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with client requirements and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.