Description

2-Chloro-N-[3-(trifluoromethyl)benzyl]acetamide is a specialized organic intermediate featuring a reactive chloroacetamide group linked to a trifluoromethyl-substituted benzyl moiety. This compound matters for its role as a versatile building block in the synthesis of more complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, where the trifluoromethyl group is valued for its ability to modulate lipophilicity, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique surface properties or chemical resistance.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for metal-organic frameworks (MOFs) or asymmetric catalysis.
• Chemical Biology Probes: Useful for creating activity-based probes or affinity tags to study enzyme function and protein interactions.

Basic Information

Product Name	2-Chloro-N-[3-(trifluoromethyl)benzyl]acetamide
CAS No.	101824-35-5
Molecular Formula	C10H9ClF3NO
Molecular Weight	251.63 g/mol
Synonyms	2-Chloro-N-[(3-(trifluoromethyl)phenyl)methyl]acetamide; N-(3-Trifluoromethylbenzyl)-2-chloroacetamide; 2-Chloroacetamide, N-[3-(trifluoromethyl)benzyl]-; Acetamide, 2-chloro-N-[3-(trifluoromethyl)benzyl]-; α-Chloro-N-(3-trifluoromethylbenzyl)acetamide; 2-Chloro-N-(3-trifluoromethylbenzyl)acetamide
EINECS	Contact for details

Quality Control

Our 2-Chloro-N-[3-(trifluoromethyl)benzyl]acetamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.