Description

4-Acetyl-2-Chlorobenzonitrile is a versatile aromatic nitrile building block characterized by its acetyl and chloro substituents, which provide distinct reactivity for advanced chemical synthesis. This compound is essential for research and development in fine chemical and pharmaceutical manufacturing, where precise molecular architecture is required. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogen and nitrile functionality.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and polymers with specific electronic or optical properties.
• Chemical Biology Probes: Utilized as a scaffold for designing molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4-Acetyl-2-Chlorobenzonitrile
CAS No.	101667-74-7
Molecular Formula	C9H6ClNO
Molecular Weight	179.60 g/mol
Synonyms	2-Chloro-4-acetylbenzonitrile; 1-(4-Cyano-3-chlorophenyl)ethanone; 4-Acetyl-2-chlorobenzene carbonitrile; 2-Chloro-4-cyanobenzophenone; 4-Cyano-3-chloroacetophenone; p-Acetyl-o-chlorobenzonitrile; 3-Chloro-4-cyanophenylethanone
EINECS	Contact for details

Quality Control

Our 4-Acetyl-2-Chlorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.