Description

Fmoc-D-Proline CAS NO 101555-62-8 is a high-purity, enantiomerically pure amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality chiral intermediates for drug discovery, peptide therapeutics, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of peptides and small proteins.
• Pharmaceutical Intermediates: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation: Serves as a chiral linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Combinatorial Chemistry: A vital component in libraries for high-throughput screening to identify new bioactive compounds.
• Proteomics & Biochemical Research: Employed in the study of protein structure-function relationships and enzyme-substrate interactions.
• Antibody-Drug Conjugate (ADC) Development: Used in constructing specialized peptide linkers for targeted drug delivery systems.

Basic Information

Product Name	Fmoc-D-Proline
CAS No.	101555-62-8
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.37 g/mol
Synonyms	(2R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid; Fmoc-D-Pro-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline; D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-Fmoc-D-proline; Fmoc-D-Pro; (R)-1-Fmoc-pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing specific results for identity, assay, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.