Description

β-Cgrp, Human is a synthetic peptide fragment corresponding to the human Calcitonin Gene-Related Peptide (CGRP), a potent neuropeptide with significant biological activity. This high-purity reference standard is critical for research and development in neuroscience, cardiovascular studies, and migraine pathophysiology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers for assay development, receptor binding studies, and as a key analytical standard.

Application

• Pharmaceutical Research & Development: As a reference standard in the development and validation of assays for CGRP-targeting therapeutics, including monoclonal antibodies and small molecule antagonists for migraine treatment.
• Neuroscience Studies: For investigating the role of CGRP in pain transmission, neurogenic inflammation, and autonomic nervous system function.
• Cardiovascular Research: Utilized in studies exploring CGRP's vasodilatory effects and its implications in vascular tone and blood pressure regulation.
• Diagnostic Kit Manufacturing: Serves as a critical component (calibrator or control) in the production of immunoassay kits for measuring CGRP levels in clinical or research samples.
• Academic & Preclinical Research: For in vitro and in vivo studies to understand receptor-ligand interactions, signal transduction pathways, and the peptide's metabolic fate.
• Quality Control & Analytical Testing: Used as a system suitability standard in HPLC, LC-MS, and other chromatographic methods within QC laboratories of biotech and pharma companies.

Basic Information

Product Name	β-Cgrp, Human
CAS No.	101462-82-2
Molecular Formula	C164H263N51O53S2
Molecular Weight	3790.3 g/mol
Synonyms	Human β-CGRP; β-CGRP (Human); Calcitonin Gene-Related Peptide, Beta Form (Human); CGRP-II (Human); β-Calcitonin Gene-Related Peptide (1-37), Human; Tyr-Calcitonin Gene-Related Peptide (23-37), Human; hCGRP-beta; hβ-CGRP; β-CGRP Fragment (Human); [Tyr0]-CGRP(23-37) (Human)
EINECS	Contact for details

Quality Control

Our β-Cgrp, Human is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets exacting standards for research and development. Certificates of Analysis (COA) detailing purity, peptide content, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.