Description

n-Desmethylrufloxacin CAS NO 101337-87-5 is a key pharmaceutical intermediate and metabolite of the fluoroquinolone antibiotic rufloxacin. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel antibacterial agents. It is primarily required by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers engaged in the development of advanced antibiotic therapies and metabolite standards.

Application

• Pharmaceutical Intermediate: Critical building block in the research and synthesis of fluoroquinolone-class antibiotics and their derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify rufloxacin metabolites in biological matrices for pharmacokinetic and toxicological research.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance, and bioavailability of rufloxacin.
• Impurity Profiling: Serves as a known impurity or degradation product standard in the quality control of rufloxacin active pharmaceutical ingredients (APIs) to ensure product safety and compliance.
• Biochemical Research: Utilized in studies exploring the mechanism of action and bacterial resistance mechanisms related to fluoroquinolone antibiotics.
• Custom Synthesis: Employed as a starting material for the custom synthesis of labeled compounds (e.g., deuterated or C13-labeled) for advanced research applications.

Basic Information

Product Name	n-Desmethylrufloxacin
CAS No.	101337-87-5
Molecular Formula	C16H15FN4O3S
Molecular Weight	362.38 g/mol
Synonyms	9-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic Acid; Desmethyl Rufloxacin; Rufloxacin Impurity; Rufloxacin Metabolite; 1,4-Dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic Acid; 6-Fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Derivative; SPA-S-272 Desmethyl Metabolite
EINECS	Contact for details

Quality Control

Our n-Desmethylrufloxacin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to guarantee traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.