Description

2-Pyrrolidinemethanol, 1-(Chloroacetyl)-, (2S)- (9Ci) is a chiral, non-racemic organic compound that serves as a versatile building block in advanced organic synthesis. Its value lies in its bifunctional structure, incorporating both a pyrrolidine ring and a chloroacetyl group, which makes it a critical intermediate for constructing complex molecules with high stereochemical fidelity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands used in asymmetric hydrogenation and other catalytic processes.
• Peptidomimetic Research: Employed in the design and synthesis of peptidomimetics and protease inhibitors due to its pyrrolidine scaffold.
• Academic & R&D Laboratories: Utilized in methodological studies and the exploration of new synthetic routes in organic chemistry.
• Fine Chemical Production: Acts as a specialized intermediate for manufacturing high-value, optically active fine chemicals and flavors/fragrances.

Basic Information

Product Name	2-Pyrrolidinemethanol, 1-(Chloroacetyl)-, (2S)- (9Ci)
CAS No.	101250-55-9
Molecular Formula	C7H12ClNO2
Molecular Weight	177.63 g/mol
Synonyms	(2S)-1-(Chloroacetyl)-2-pyrrolidinemethanol; (S)-1-(Chloroacetyl)-2-(hydroxymethyl)pyrrolidine; L-1-(Chloroacetyl)-2-pyrrolidinemethanol; 1-Chloroacetyl-2-pyrrolidinemethanol, (S)-; 2-Pyrrolidinemethanol, 1-(chloroacetyl)-, (S)-; (S)-2-(Hydroxymethyl)-1-(2-chloroacetyl)pyrrolidine; (S)-N-(Chloroacetyl)prolinol; (S)-1-Chloroacetyl-2-hydroxymethylpyrrolidine
EINECS	Contact for details

Quality Control

Our production of 2-Pyrrolidinemethanol, 1-(Chloroacetyl)-, (2S)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and scale-up. Each lot is characterized using advanced analytical techniques, including chiral HPLC to confirm enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.