Description

Buprenorphine B-D-Glucuronide is a major, pharmacologically active metabolite of the opioid partial agonist buprenorphine. This compound is critical for analytical and research purposes, serving as a primary reference standard for the quantification of buprenorphine and its metabolites in biological matrices. It is essential for pharmaceutical R&D, forensic toxicology, and clinical laboratories focused on drug metabolism studies, therapeutic drug monitoring, and compliance testing.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration and validation of analytical methods in drug development and quality control.
• Forensic Toxicology: Critical for the accurate identification and quantification of buprenorphine exposure in urine, blood, and hair samples for legal and workplace testing.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables precise measurement of buprenorphine metabolite levels in patients undergoing treatment for opioid use disorder or pain management.
• Pharmacokinetic & Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the metabolic pathways and clearance of buprenorphine.
• Bioanalytical Method Development: Serves as a key component in developing and optimizing HPLC, LC-MS/MS, and GC-MS assays for high-sensitivity detection.
• Manufacturing Process Control: Acts as a benchmark for impurity profiling and ensuring the consistency and purity of buprenorphine-based pharmaceutical products.

Basic Information

Product Name	Buprenorphine B-D-Glucuronide
CAS No.	101224-22-0
Molecular Formula	C33H47NO9
Molecular Weight	601.73 g/mol
Synonyms	Buprenorphine 3-β-D-Glucuronide; Buprenorphine Glucuronide; Buprenorphine D-Glucuronide; Nor-buprenorphine-3-glucuronide (related); BUP-Gluc; (2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(4-((2S)-2-((5R,6R,7R,14S)-9α-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl)-3-hydroxybutoxy)-3-methoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Buprenorphine B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous identity confirmation, purity analysis, and impurity profiling using advanced chromatographic and spectroscopic techniques to ensure it meets the high standards required for reference materials. Certificates of Analysis (COA) with detailed chromatographic data, including HPLC purity and related substance profiles, are provided for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.