Description

Substance P, Pyridoxal-Phosphate(6)-Lys(3)- CAS NO 101213-42-7 is a chemically modified peptide derivative, combining the neuropeptide Substance P with a pyridoxal phosphate moiety linked via a lysine residue. This compound is significant for its role as a research-grade biochemical tool in advanced neuroscience and cellular signaling studies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and diagnostic developers investigating neurokinin receptor interactions, vitamin B6-dependent enzymatic processes, and targeted drug delivery mechanisms.

Application

• Neuroscience Research: Used as a key reagent in studying the binding affinity, metabolism, and signaling pathways of Substance P and its receptors (NK1).
• Enzymology Studies: Serves as a substrate or inhibitor analog in research on pyridoxal phosphate (PLP)-dependent enzymes, such as transaminases and decarboxylases.
• Bioconjugation & Probe Development: Acts as a starting material for creating fluorescently labeled or affinity-tagged probes for cellular imaging and receptor localization.
• Drug Discovery Platforms: Employed in high-throughput screening assays to identify and characterize novel modulators of neuropeptide-related targets for pain, inflammation, and CNS disorders.
• Biochemical Standard: Provides a characterized reference standard for quality control in the production of related peptide-based active pharmaceutical ingredients (APIs).
• Metabolic Pathway Analysis: Facilitates research into the interplay between neuropeptide signaling and vitamin B6 metabolism in cellular models.

Basic Information

Product Name	Substance P, Pyridoxal-Phosphate(6)-Lys(3)-
CAS No.	101213-42-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Substance P PLP Conjugate; Pyridoxal-5'-phosphate-Lys(3)-Substance P; [Lys(3)(Pyridoxal-5'-phosphate)]-Substance P; SP-PLP Conjugate; Neurokinin-PLP Derivative; PLP-Substance P Analog; Substance P Pyridoxal Phosphate Adduct
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. For this research-grade biochemical, quality is assured through multiple orthogonal analytical techniques, including HPLC for purity, mass spectrometry for identity confirmation, and NMR for structural verification. We adhere to a cGMP-inspired quality management system to ensure batch-to-batch consistency and traceability for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use and storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.