Description

α-Helical Corticotropin Releasing Hormone (3-41), Tyr(3), Pro(4), Nle(18,21)- is a synthetic, stabilized analog of the neuropeptide corticotropin-releasing hormone (CRH), designed for enhanced biological activity and stability in research applications. This modified peptide is critical for studying the hypothalamic-pituitary-adrenal (HPA) axis, stress response mechanisms, and related neurological pathways. It is an essential research-grade biochemical for neuroscientists, endocrinologists, and pharmaceutical developers in academic, clinical, and industrial R&D settings.

Application

• Neuroscience Research: Investigation of CRH receptor (CRHR1/CRHR2) binding, activation, and downstream signaling cascades.
• Endocrinology Studies: Probing the regulation of the HPA axis, adrenocorticotropic hormone (ACTH) release, and glucocorticoid production.
• Stress & Behavioral Pharmacology: Used in animal models to study anxiety, depression, and stress-related behaviors.
• Drug Discovery & Development: Serving as a reference standard or tool compound in high-throughput screening for novel CRH receptor antagonists or modulators.
• Biochemical Assay Development: Utilized in ELISA, RIA, or cell-based assays to quantify biological activity and receptor affinity.
• Academic & Clinical Research: Fundamental research into the role of CRH in various physiological and pathological conditions.

Basic Information

Product Name	α-Helical Corticotropin Releasing Hormone (3-41), Tyr(3), Pro(4), Nle(18,21)-
CAS No.	101178-72-7
Molecular Formula	C212H342N64O58S2
Molecular Weight	4697.5 g/mol (approximately)
Synonyms	α-Helical CRH (3-41); αh-CRH; Tyr(3), Pro(4), Nle(18,21)-CRH(3-41); Corticotropin-Releasing Factor (3-41), α-helical; CRF (3-41), α-helical; α-Helical Corticotropin Releasing Factor (3-41); h/rCRH(3-41); Stabilized CRH Analog
EINECS	Contact for details

Quality Control

Our research-grade peptides are produced and analyzed under stringent conditions to ensure high purity, accurate sequence, and consistent biological activity. Each batch is supported by comprehensive analytical data, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid, or suitable aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.