Description

2-Butanamine, 4,4,4-Trifluoro-, Hydrochloride, (S)- (9Ci) is a high-purity, single-enantiomer chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for introducing a trifluoromethyl-bearing chiral center, a structural motif known to enhance the metabolic stability and bioavailability of target molecules. It is primarily needed by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the (S)-configured trifluoromethyl-amine moiety can impart superior biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis to create other enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials where fluorinated chiral units can modify physical properties like solubility, thermal stability, and optical activity.
• Chemical Biology & Proteomics: Utilized as a building block for activity-based probes and molecular tags to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Butanamine, 4,4,4-Trifluoro-, Hydrochloride, (S)- (9Ci)
CAS No.	101055-00-9
Molecular Formula	C4H9ClF3N
Molecular Weight	163.57 g/mol
Synonyms	(S)-4,4,4-Trifluoro-2-butanamine hydrochloride; (S)-4,4,4-Trifluorobutane-2-amine hydrochloride; (S)-1,1,1-Trifluoro-3-aminobutane hydrochloride; (S)-γ,γ,γ-Trifluoroisobutylamine hydrochloride; (S)-3-Amino-1,1,1-trifluorobutane hydrochloride; (S)-TFBA HCl; (S)-Trifluorobutylamine hydrochloride; (S)-4,4,4-Trifluorobutan-2-aminium chloride
EINECS	Contact for details

Quality Control

Our 2-Butanamine, 4,4,4-Trifluoro-, Hydrochloride, (S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC/SFC), to ensure compliance with exacting standards for research and development use. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/SFC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.