Description

Terephthalamic Acid, n-(6-Amino-1,2,3,4-Tetrahydro-1,3-Dimethyl-2,4-Dioxo-5-Pyrimidinyl)-, Methyl Ester (6Ci) is a specialized heterocyclic organic compound that serves as a critical advanced pharmaceutical intermediate and building block in fine chemical synthesis. Its unique molecular structure, featuring both a pyrimidinedione core and a terephthalamic ester moiety, makes it invaluable for constructing complex molecules with specific biological activities. This high-purity intermediate is primarily sought by pharmaceutical R&D and contract manufacturing organizations (CMOs) engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel therapeutic agents, particularly in oncology and antiviral research.
• Nucleic Acid Analog Development: Used in the research and production of modified nucleosides and nucleotides.
• Bioconjugation Chemistry: Serves as a linker or functional handle for attaching payloads in antibody-drug conjugates (ADCs) and other targeted therapies.
• Agrochemical Research: Intermediate in the development of new pesticides and herbicides with specific modes of action.
• Material Science: Potential monomer for creating specialized polymers with unique thermal or optical properties.
• Academic & Industrial R&D: Used in chemical libraries for high-throughput screening and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Terephthalamic Acid, n-(6-Amino-1,2,3,4-Tetrahydro-1,3-Dimethyl-2,4-Dioxo-5-Pyrimidinyl)-, Methyl Ester (6Ci)
CAS No.	100975-06-2
Molecular Formula	C15H16N4O5
Molecular Weight	332.31 g/mol
Synonyms	Methyl N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)terephthalamate; 5-[[(2-Carboxyphenyl)carbonyl]amino]-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione methyl ester; 6-Amino-1,3-dimethyl-5-[[(2-methoxycarbonylphenyl)carbonyl]amino]-2,4(1H,3H)-pyrimidinedione; Terephthalamic acid, N-(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-, methyl ester; 1,3-Dimethyl-6-[(2-methoxycarbonylbenzoyl)amino]pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our production of Terephthalamic Acid, n-(6-Amino-1,2,3,4-Tetrahydro-1,3-Dimethyl-2,4-Dioxo-5-Pyrimidinyl)-, Methyl Ester (6Ci) adheres to stringent cGMP and ISO 9001 quality management principles. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support full regulatory documentation for pre-clinical and clinical-stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.