Description

Gly-Pro 4-Methoxy-β-Naphthylamide Hydrochloride is a specialized dipeptide derivative used as a critical biochemical reagent and synthetic intermediate. This compound is valued for its role as a chromogenic substrate for the detection and study of specific proteolytic enzymes, particularly dipeptidyl peptidases. It is primarily utilized by research institutions, pharmaceutical development laboratories, and diagnostic manufacturers requiring high-purity, well-characterized substrates for enzymatic assays and biochemical research.

Application

• Enzymology Research: Acts as a specific chromogenic substrate for the assay of dipeptidyl peptidase IV (DPP-IV) and related proline-specific peptidases.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) platforms to identify and characterize potential inhibitors of DPP-IV, a target for type 2 diabetes and other therapeutic areas.
• Diagnostic Reagent Manufacturing: Incorporated into kits for the clinical measurement of DPP-IV activity in serum or tissue samples.
• Biochemical Pathway Analysis: Employed in studies of peptide metabolism and the role of specific peptidases in physiological and pathological processes.
• Peptide Synthesis Intermediate: Serves as a protected building block or a model compound in the synthesis of more complex peptide structures.
• Cell Biology & Immunology: Used in research investigating T-cell activation and immune function, where DPP-IV (CD26) plays a significant role.

Basic Information

Product Name	Gly-Pro 4-Methoxy-β-Naphthylamide Hydrochloride
CAS No.	100929-90-6
Molecular Formula	C₁₈H₂₁N₃O₃·HCl
Molecular Weight	363.84 g/mol
Synonyms	Glycyl-L-proline 4-methoxy-2-naphthylamide hydrochloride; Gly-Pro-4-MeO-β-NA·HCl; H-Gly-Pro-4-methoxy-β-naphthylamide hydrochloride; L-Glycyl-L-proline 4-methoxy-2-naphthylamide monohydrochloride; DPP-IV Substrate (4-Methoxy-β-naphthylamide derivative); GP-4MβNA·HCl; 4-Methoxy-2-naphthylamide-Gly-Pro; Substrate for Dipeptidyl Peptidase IV
EINECS	Contact for details

Quality Control

Our Gly-Pro 4-Methoxy-β-Naphthylamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and verification of physical properties. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.