Description

Methionine Enkephalinamide Acetate Salt is a synthetic peptide analog of the endogenous opioid peptide methionine enkephalin, modified at the C-terminus to enhance its stability and biological activity. This compound is a critical research tool for studying opioid receptor pharmacology, signal transduction pathways, and the physiological roles of enkephalins in the nervous system. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and neuropsychiatric disorders.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and functional studies to investigate mu and delta opioid receptor subtypes.
• Pharmacological Studies: Serves as a reference standard and active agent in vitro and in vivo to study analgesia, tolerance, and dependence mechanisms.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays for drug discovery targeting the opioid system.
• Cell Signaling Research: Applied to study G-protein coupled receptor (GPCR) activation, intracellular calcium mobilization, and kinase pathways influenced by opioid peptides.
• Standards and Controls: Functions as a high-purity analytical standard for HPLC, LC-MS, and other chromatographic methods in quality control and metabolic studies.

Basic Information

Product Name	Methionine Enkephalinamide Acetate Salt
CAS No.	100929-67-7
Molecular Formula	C28H38N6O7S • xC2H4O2
Molecular Weight	614.71 g/mol (Free base)
Synonyms	Met-Enkephalinamide Acetate; Tyr-Gly-Gly-Phe-Met-NH2 Acetate; Methionine Enkephalin Amide Acetate; Opioid Peptide [Met5]-Enkephalinamide Acetate; H-Tyr-Gly-Gly-Phe-Met-NH2 • AcOH; YGGFM-NH2 Acetate; MEAM Acetate; [Met5]-Enkephalin Amide Acetate Salt
EINECS	Contact for details

Quality Control

Our Methionine Enkephalinamide Acetate Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not intended for human therapeutic use, production adheres to principles of current Good Manufacturing Practice (cGMP) where applicable for research-grade peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular mass
Purity (HPLC)	≥ 95.0%
Assay (Content)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	3.0 - 8.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.