Description

[D-Trp11]-Neurotensin is a synthetic, biologically active peptide analog of the endogenous neuropeptide Neurotensin. This modified compound is engineered for enhanced metabolic stability and receptor selectivity, making it a critical tool for advanced neuroscience and pharmacological research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurobiology, receptor studies, and drug discovery programs.

Application

• Neuroscience Research: As a potent and selective ligand for studying Neurotensin receptor (NTS1/NTS2) signaling pathways, function, and distribution in the central nervous system.
• Pharmacological Studies: Used in in vitro and in vivo assays to investigate the physiological roles of neurotensin, including its effects on dopamine transmission, analgesia, and hypothermia.
• Drug Discovery & Development: Serves as a reference standard and a lead compound for developing novel therapeutics targeting neuropsychiatric disorders, pain, and cancers where neurotensin receptors are implicated.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays, receptor binding studies, and functional cellular assays.
• Academic & Clinical Research: A key reagent for fundamental research into the role of neuropeptides in behavior, addiction, and neurodegenerative diseases.

Basic Information

Product Name	[D-Trp11]-Neurotensin
CAS No.	100929-52-0
Molecular Formula	C₇₈H₁₂₁N₂₁O₂₀
Molecular Weight	1673.9 g/mol
Synonyms	D-Tryptophan(11)-Neurotensin; Neurotensin (8-13), D-Trp-11-; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH; D-Trp(11)]NT(8-13); NT(8-13) analog; Neurotensin fragment 8-13 analog; [D-Trp¹¹]-NT
EINECS	Contact for details

Quality Control

Every batch of [D-Trp11]-Neurotensin is manufactured under controlled conditions and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol includes rigorous methods such as HPLC for purity determination, mass spectrometry for structural confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 70.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPIC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.