Description

(Val4)-Angiotensin III CAS NO 100900-28-5 is a synthetic peptide analog of the endogenous vasoactive hormone angiotensin III, specifically modified at the fourth position with a valine residue. This modification is critical for enhancing receptor selectivity and metabolic stability in research applications. It serves as a valuable biochemical tool for studying the renin-angiotensin system (RAS), particularly the roles of angiotensin II type 2 (AT2) and other non-classical receptors. This high-purity compound is essential for pharmaceutical R&D, academic research in cardiovascular physiology, and the development of novel diagnostic assays.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating the pathophysiology of hypertension, heart failure, and renal diseases.
• Receptor Binding Assays: Essential for characterizing binding affinity and selectivity at angiotensin receptor subtypes (AT1, AT2, AT4) in vitro.
• Biochemical Pathway Analysis: A key tool for elucidating signal transduction mechanisms within the Renin-Angiotensin-Aldosterone System (RAAS).
• Drug Discovery & Development: Serves as a precursor or analog in the design and screening of new cardiovascular and neuroprotective therapeutics.
• Diagnostic Kit Manufacturing: Employed in the production of calibration standards and controls for immunoassays measuring angiotensin peptides.
• Academic & Institutional Studies: Supports basic science research in universities and medical institutes focusing on endocrinology and peptide biology.

Basic Information

Product Name	(Val4)-Angiotensin III
CAS No.	100900-28-5
Molecular Formula	C49H70N14O10
Molecular Weight	1031.2 g/mol
Synonyms	Angiotensin III, Val4-analog; [Val4]-Angiotensin III; Asp-Arg-Val-Tyr-Val-His-Pro-Phe; DRVYVHPF; Angiotensin (3-8), Val4-; Angiotensin III (Val4); H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH
EINECS	Contact for details

Quality Control

Every batch of (Val4)-Angiotensin III is manufactured and analyzed under strict quality management protocols to ensure the highest standards of purity and identity. Our products undergo rigorous quality testing, including multiple orthogonal analytical methods, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA), detailing purity, identity confirmation, and impurity profiles, is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.