Description

n-Cbz-Ala-Ala-Lys 4-Methoxy-B-*Naphthylamide Formate is a specialized synthetic peptide derivative, primarily utilized as a high-purity biochemical reagent and research tool. This compound is critical for advancing studies in enzymology, proteomics, and the development of novel therapeutic agents. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise and reliable substrates for enzyme activity assays, particularly for proteases like cathepsins.

Application

• Enzyme Substrate for Protease Research: Acts as a fluorogenic or chromogenic substrate for studying the kinetics and inhibition of serine and cysteine proteases, including cathepsins and related enzymes.
• Biochemical Assay Development: Used in high-throughput screening (HTS) platforms to identify and characterize new enzyme inhibitors for drug discovery programs.
• Proteomics and Cell Biology: Employed in assays to detect and quantify specific protease activity within complex biological samples, aiding in the study of cellular processes and disease mechanisms.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the research and development of targeted therapies, particularly in oncology and inflammatory diseases.
• Diagnostic Reagent Manufacturing: Incorporated into the formulation of diagnostic kits for clinical laboratories to measure specific enzyme levels.

Basic Information

Product Name	n-Cbz-Ala-Ala-Lys 4-Methoxy-B-*Naphthylamide Formate
CAS No.	100900-14-9
Molecular Formula	C34H44N6O8 • HCOOH
Molecular Weight	~704.77 g/mol (Free base: 664.75 g/mol)
Synonyms	N-Carbobenzoxy-Ala-Ala-Lys 4-Methoxy-2-Naphthylamide Formate; Z-Ala-Ala-Lys-4-Methoxy-β-NA Formate; CBZ-Ala-Ala-Lys-4-Methoxy-2-Naphthylamide Formate; Ala-Ala-Lys 4-Methoxy-2-Naphthylamide, N-[(phenylmethoxy)carbonyl]-; Fluorogenic Cathepsin Substrate; Protease Substrate 4-Methoxy-β-NA; Z-A-A-K 4-Methoxy-β-NA Formate
EINECS	Contact for details

Quality Control

Our n-Cbz-Ala-Ala-Lys 4-Methoxy-B-*Naphthylamide Formate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.