Description

Tos-Gly-Pro-Oh CAS NO 100723-71-5 is a protected tripeptide derivative, specifically a tosyl-glycyl-proline, widely utilized as a crucial building block in peptide synthesis. This compound is valued for its role in constructing complex peptide sequences, where the tosyl (Tos) group acts as a protective moiety for the N-terminus. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel therapeutic peptides and biochemical probes.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of therapeutic peptides targeting various diseases.
• Biochemical Research: Used in academic and industrial R&D for studying enzyme-substrate interactions, protease mechanisms, and peptide structure-activity relationships (SAR).
• Peptide Library Construction: Employed in combinatorial chemistry for generating diverse peptide libraries used in high-throughput screening for drug discovery.
• API Development: Serves as a critical intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) with proline-containing sequences.
• Protease Inhibitor Synthesis: Acts as a precursor in the development of peptide-based protease inhibitors, which are important for treating conditions like hypertension and viral infections.
• Diagnostic Reagent Production: Utilized in the manufacture of specialized peptides for diagnostic kits and biomarker detection assays.

Basic Information

Product Name	Tos-Gly-Pro-Oh
CAS No.	100723-71-5
Molecular Formula	C₁₇H₂₂N₂O₆S
Molecular Weight	382.43 g/mol
Synonyms	N-p-Tosylglycyl-L-proline; Tos-Gly-Pro-OH; p-Toluenesulfonyl-Gly-Pro-OH; Glycylproline N-tosyl derivative; L-Proline, N-[(phenylmethoxy)carbonyl]glycyl- (related); TGP; Tosyl-Gly-Pro; N-Tosylglycyl-L-proline
EINECS	Contact for details

Quality Control

Our Tos-Gly-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via IR and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Proline isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.