Description

Hypoxanthine Monohydrochloride, [8-3H] is a tritium-labeled derivative of the purine base hypoxanthine, specifically radiolabeled at the 8-position. This compound is a critical tool for researchers requiring high-sensitivity detection and quantification in metabolic and biochemical studies. It is primarily utilized in life science research, pharmaceutical development, and diagnostic assay development for tracing nucleic acid metabolism and related pathways.

Application

• Biochemical Research: As a radiolabeled tracer in studies of purine and nucleotide metabolism, salvage pathways, and enzyme kinetics.
• Pharmaceutical Development: For drug metabolism and pharmacokinetics (DMPK) studies to track the incorporation and fate of nucleoside analogs.
• Diagnostic Assay Development: Used in the development of radioimmunoassays (RIAs) and other sensitive detection methods for research purposes.
• Cell Biology Studies: Investigating DNA/RNA synthesis, cell proliferation, and the mechanisms of action of chemotherapeutic agents.
• Enzymology: Serving as a substrate for enzymes such as hypoxanthine-guanine phosphoribosyltransferase (HGPRT).

Basic Information

Product Name	Hypoxanthine Monohydrochloride, [8-3H]
CAS No.	100694-13-1
Molecular Formula	C5H5N4O • HCl (with 3H label)
Molecular Weight	172.57 g/mol (unlabeled base)
Synonyms	6-Hydroxypurine hydrochloride, [8-3H]; 1,7-Dihydro-6H-purin-6-one monohydrochloride, [8-3H]; Hypoxanthine HCl, tritiated; [3H]-Hypoxanthine hydrochloride; Tritium-labeled hypoxanthine HCl; Purine-6-ol, hydrochloride, [8-3H]; 6-Oxopurine hydrochloride, [8-3H]
EINECS	Contact for details

Quality Control

Our radiolabeled compounds are produced and controlled under a strict quality management system. Each batch is analyzed to ensure high radiochemical purity and specific activity as specified. Certificates of Analysis (COA) detailing radioactivity concentration, purity (by HPLC), and solvent composition are provided with every shipment to ensure traceability and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the original container in a designated, well-ventilated freezer. Users must follow all applicable radiation safety regulations for handling and storage.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-30 Ci/mmol (Contact for specific value)
Radioactivity Concentration	1 mCi/mL ± 10% (in specified solvent)
Solvent	Ethanol:Water or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.