Description

n-[(1S,2R)-2-Hydroxy-1,2-Diphenylethyl]-Glycine Ethyl Ester is a high-purity chiral glycine derivative, serving as a critical building block in asymmetric synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with high enantiomeric purity. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and advanced chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including enzyme inhibitors and receptor modulators.
• Asymmetric Catalyst Ligand Precursor: Used to synthesize sophisticated ligands for transition metal catalysts employed in enantioselective hydrogenation, oxidation, and C-C bond formation reactions.
• Peptidomimetic Research: Serves as a constrained, non-natural amino acid analog for designing and synthesizing peptide mimics with enhanced stability and biological activity.
• Organic Synthesis Building Block: Utilized in multi-step syntheses to introduce chiral 1,2-amino alcohol functionalities into target molecules.
• Academic & Process Chemistry: A valuable reagent for methodological development in academic laboratories and for scaling up chiral processes in industrial settings.

Basic Information

Product Name	n-[(1S,2R)-2-Hydroxy-1,2-Diphenylethyl]-Glycine Ethyl Ester
CAS No.	100678-82-8
Molecular Formula	C₁₈H₂₁NO₃
Molecular Weight	299.37 g/mol
Synonyms	(S,R)-2-Hydroxy-1,2-diphenylethylglycine ethyl ester; Ethyl (2S,3R)-2-(hydroxy(diphenyl)methyl)-3-aminopropanoate; (1S,2R)-1,2-Diphenyl-2-hydroxyethylaminoacetic acid ethyl ester; Glycine, N-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]-, ethyl ester; NSC 339586; (S,R)-HPG-OEt; Chiral glycine ethyl ester derivative
EINECS	Contact for details

Quality Control

Our n-[(1S,2R)-2-Hydroxy-1,2-Diphenylethyl]-Glycine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.