Description

1,23,25,26-Tetrahydroxyvitamin D3 is a highly active metabolite of vitamin D, representing a key intermediate in the hormonal calcitriol pathway. This compound is critical for advanced research into calcium homeostasis, cell differentiation, and immune system modulation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity reference standards and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: Serves as a crucial reference standard and intermediate in the synthesis and study of novel vitamin D analogs and metabolites for therapeutic applications.
• Biochemical Studies: Used to investigate the nuanced mechanisms of vitamin D receptor (VDR) activation, gene regulation, and non-classical signaling pathways.
• Metabolic Pathway Analysis: Essential for studying the complex enzymatic conversion steps within the vitamin D metabolic cascade, particularly in relation to kidney and bone physiology.
• Reference Material Production: Sourced for the preparation of certified reference materials (CRMs) and high-purity calibrants used in analytical laboratories.
• Nutraceutical Advanced Research: Employed in the development of next-generation nutritional supplements targeting specific metabolic functions.

Basic Information

Product Name	1,23,25,26-Tetrahydroxyvitamin D3
CAS No.	100634-18-2
Molecular Formula	C₂₇H₄₄O₅
Molecular Weight	448.64 g/mol
Synonyms	1,23,25,26-Tetrahydroxycholecalciferol; 1α,23S,25R,26-Tetrahydroxyvitamin D3; 1α,23S,25R,26-Tetrahydroxycholecalciferol; 1,23,25,26-Tetrahydroxy-D3; Tetrahydroxyvitamin D3; Vitamin D3 metabolite (1,23,25,26-tetrahydroxy); 1α,23S,25R,26-Tetrahydroxyvitamin D₃
EINECS	Contact for details

Quality Control

Every batch of 1,23,25,26-Tetrahydroxyvitamin D3 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.