Description

Tyr-Corticotropin Releasing Factor Human, Rat CAS NO 100513-58-4 is a synthetic peptide analog of corticotropin-releasing factor (CRF), a key neurohormone involved in the body's stress response system. This high-purity research-grade compound is essential for advanced biochemical and pharmacological studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies investigating the hypothalamic-pituitary-adrenal (HPA) axis, stress-related disorders, and neuroendocrine signaling pathways.

Application

• Neuroscientific Research: Used as a critical tool for studying the central nervous system's response to stress, anxiety, and depression.
• Endocrinology Studies: Applied in vitro and in vivo to investigate the regulation of adrenocorticotropic hormone (ACTH) release from the pituitary gland.
• Pharmacological Screening: Serves as a reference standard and active agent in high-throughput screening for novel CRF receptor antagonists and modulators.
• Biomarker Development: Utilized in the development and validation of immunoassays and other diagnostic methods for measuring CRF-related activity.
• Preclinical Animal Models: Employed to establish and study animal models of stress-related physiological and behavioral conditions.
• Peptide Chemistry Reference: Acts as a precise molecular standard in mass spectrometry and chromatographic analysis for peptide identification and quantification.

Basic Information

Product Name	Tyr-Corticotropin Releasing Factor Human, Rat
CAS No.	100513-58-4
Molecular Formula	C208H344N60O63S
Molecular Weight	4759.4 g/mol
Synonyms	Tyr-CRF; Tyr-Corticotropin Releasing Hormone; Tyr-CRF (human, rat); h/r Tyr-CRF; O-Tyrosyl-Corticotropin Releasing Factor; CRF, Tyr-; Tyr0-CRF; Tyr-CRF Peptide; Corticoliberin, O-Tyrosyl-; Stresscopin-related peptide analog
EINECS	Contact for details

Quality Control

Our Tyr-Corticotropin Releasing Factor is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to stringent analytical standards, utilizing techniques such as HPLC and mass spectrometry to verify product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.