Description

Technetium Tc 99M Exametazime is a diagnostic radiopharmaceutical agent used in nuclear medicine imaging. Its primary value lies in its ability to cross the intact blood-brain barrier, allowing for the assessment of regional cerebral blood flow. This makes it a critical tool for neurologists and radiologists in hospitals and diagnostic imaging centers worldwide. It is essential for single-photon emission computed tomography (SPECT) scans to evaluate conditions such as stroke, dementia, and epilepsy.

Application

• Cerebral Perfusion Imaging: Primary application for assessing regional cerebral blood flow (rCBF) in patients.
• Stroke Evaluation: Used to identify areas of ischemia and evaluate the extent of brain tissue at risk.
• Dementia Diagnosis: Aids in differentiating between types of dementia, such as Alzheimer's disease and frontotemporal dementia, based on perfusion patterns.
• Epilepsy Focus Localization: Helps in localizing the epileptogenic focus, particularly in patients being evaluated for surgery.
• Brain Trauma Assessment: Used to evaluate cerebral perfusion following head injury.
• Pharmacological Research: Employed in clinical trials to study the effects of new drugs on cerebral blood flow.

Basic Information

Product Name	Technetium Tc 99M Exametazime
CAS No.	100504-35-6
Molecular Formula	C₂₀H₃₂N₆O₄·⁹⁹ᵐTc
Molecular Weight	~ 532.5 g/mol (for ligand, excluding isotope mass)
Synonyms	Exametazime; HM-PAO; Ceretec; Hexamethylpropyleneamine Oxime; d,l-HMPAO; Technetium (99mTc) Exametazime; Bicisate; Neurolite; RP-51723; Tc-99m HMPAO
EINECS	Contact for details

Quality Control

Every batch of Technetium Tc 99M Exametazime is manufactured and released under strict radiopharmaceutical Good Manufacturing Practice (GMP) guidelines. Quality control includes rigorous testing for radiochemical purity, radiolabeling efficiency, sterility, and apyrogenicity to ensure patient safety and imaging efficacy. A comprehensive Certificate of Analysis (COA) detailing all release specifications is provided with each shipment.

Storage

Preserve in the original, shielded, and tightly closed container as supplied. Store at controlled room temperature (15-25°C) or as directed. This product is light-sensitive (store away from light) and the technetium-99m complex is easily oxidized (store under inert atmosphere). It is for diagnostic use only and must be administered within the recommended time frame post-reconstitution due to radioactive decay.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
pH	6.5 - 7.5
Radiochemical Purity (HPLC)	≥ 90%
Radionuclidic Purity (Gamma Spectroscopy)	≥ 99.0% (Tc-99m)
Chemical Purity (HPLC)	Meets established limits for Exametazime ligand
Sterility Test (Membrane Filtration)	Sterile
Bacterial Endotoxins (LAL)	< 175 EU/Vial

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.