Description

Hemoglobin F Shanghai CAS NO 100365-95-5 is a high-purity, research-grade preparation of fetal hemoglobin, the primary oxygen-transporting protein in the developing fetus. This compound is of critical importance for biochemical research, diagnostic development, and therapeutic studies due to its unique oxygen-binding properties and relevance to hemoglobinopathies. It is an essential reagent for researchers and manufacturers in the fields of hematology, clinical diagnostics, pharmaceutical R&D, and biotechnology, where precise and reliable protein standards are required.

Application

• Biochemical Research & Standardization: Used as a primary standard in spectroscopic studies, oxygen affinity assays, and protein interaction research.
• Diagnostic Kit Manufacturing: Serves as a critical calibrant and control material in the production of immunoassays and chromatography-based tests for hemoglobin variants.
• Pharmaceutical Development: Employed in studies exploring treatments for sickle cell disease, β-thalassemia, and other disorders involving abnormal hemoglobin.
• Clinical Laboratory Reference: Provides a definitive reference material for the identification and quantification of HbF in patient samples via HPLC or electrophoresis.
• Academic & Educational Use: An essential teaching tool in university laboratories for courses in biochemistry, molecular biology, and medical technology.
• Biomaterial & Biosensor Development: Investigated for use in the creation of oxygen-sensing platforms and novel hemoglobin-based oxygen carriers (HBOCs).

Basic Information

Product Name	Hemoglobin F Shanghai
CAS No.	100365-95-5
Molecular Formula	C2952H4664N812O840S8Fe4
Molecular Weight	~64,500 Da
Synonyms	Fetal Hemoglobin; Hb F; Hemoglobin F; α2γ2 Hemoglobin; γ-Globin Tetramer; Fetal Haemoglobin; Hemoglobin, Fetal; CAS 100365-95-5
EINECS	Contact for details

Quality Control

Our Hemoglobin F is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is characterized for identity, purity, and functional activity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as purity by HPLC, spectral properties (A540/A280 ratio), and endotoxin levels. We adhere to relevant guidelines for biological reference materials to support your compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to prevent degradation. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use in a low-humidity environment.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR)	Conforms to standard
Purity (HPLC)	≥ 95% (HbF)
Methemoglobin Content	≤ 5%
Absorbance Ratio (A540/A280)	≥ 2.0
Protein Content (Biuret)	≥ 90%
Endotoxin	< 10 EU/mg
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.