Description

25-Desacetyl Rifabutin is a key pharmaceutical intermediate and metabolite of the antibiotic rifabutin. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the synthesis and analytical profiling of anti-tuberculosis and anti-Mycobacterium avium complex (MAC) agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories involved in drug development, metabolite studies, and quality control processes for rifabutin-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and development of rifabutin and related antibiotic compounds.
• Reference Standard: Used as a high-purity chemical standard in analytical laboratories for HPLC, LC-MS, and other chromatographic methods to quantify rifabutin and its metabolites.
• Metabolite Research: Essential for pharmacokinetic and pharmacodynamic studies to understand the metabolism, efficacy, and safety profile of rifabutin.
• Impurity Profiling: Employed in the identification and qualification of process-related impurities and degradation products in rifabutin drug substances and finished products.
• Bioanalytical Method Development: Serves as a key analyte in developing and validating assays for biological samples in clinical trials.
• Active Pharmaceutical Ingredient (API) Development: Supports research into new formulations and derivatives of rifamycin-class antibiotics.

Basic Information

Product Name	25-Desacetyl Rifabutin
CAS No.	100324-63-8
Molecular Formula	C45H58N4O10
Molecular Weight	822.97 g/mol
Synonyms	LM 565; Desacetylrifabutin; 25-O-Desacetylrifabutin; Rifabutin Metabolite LM 565; 25-Desacetylrifabutin; 4-Deoxy-3,4-[2-spiro(N-isobutyl-4-piperidyl)]-(1H)-imidazo[2,1-b]purine-2(3H),7(4H)-dione; (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6,16,18,20-Tetrahydroxy-1'-isobutyl-14-methoxy-7,9,15,17,19,21,25-heptamethyl-8,30-dioxo-11,31-dioxa-2-azatetracyclo[24.2.1.14,7.05,28]hentriaconta-3,5(28),12,22,24-pentaene-23-carboxylic acid
EINECS	Contact for details

Quality Control

Our 25-Desacetyl Rifabutin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by validated methods (e.g., HPLC, NMR) are provided with every shipment to guarantee traceability and compliance with your quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.