Description

Cyproheptadine n-Oxide is a key pharmaceutical intermediate and metabolite of the antihistamine cyproheptadine. This compound matters for its critical role in drug metabolism studies, analytical reference standard preparation, and the research and development of new therapeutic agents. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in pharmacokinetics, impurity profiling, and quality control of related drug substances.

Application

• Pharmaceutical Intermediate: Used in the synthesis and research of cyproheptadine-based pharmaceuticals.
• Metabolite Reference Standard: Serves as a certified reference material (CRM) for drug metabolism and pharmacokinetic (DMPK) studies.
• Analytical Chemistry: Employed as an impurity standard in HPLC and LC-MS methods for quality control of active pharmaceutical ingredients (APIs).
• Pharmacological Research: Utilized in preclinical studies to understand the metabolic pathways and biological activity of cyproheptadine.
• Regulatory Compliance: Supports analytical method development and validation for regulatory filings (e.g., FDA, EMA).

Basic Information

Product Name	Cyproheptadine n-Oxide
CAS No.	100295-63-4
Molecular Formula	C21H21NO
Molecular Weight	303.40 g/mol
Synonyms	1-Methyl-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine N-Oxide; Periactin Metabolite; Cyproheptadine N-Oxide; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine 1-Oxide; 5-(1-Methyl-4-piperidylidene)-5H-dibenzo[a,d]cycloheptene N-Oxide; N-Oxide of Cyproheptadine; Cyproheptadine Oxide
EINECS	Contact for details

Quality Control

Our Cyproheptadine n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification, purity assay, and impurity profiling by HPLC, to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.