Description

Hemoglobin J Sardegna CAS NO 100205-23-0 is a specific variant of hemoglobin, a critical oxygen-transporting metalloprotein found in red blood cells. This compound is of significant interest in biochemical research and diagnostic development due to its role in studying hemoglobinopathies and oxygen-binding kinetics. It is primarily utilized by research institutions, clinical diagnostic laboratories, and pharmaceutical developers focused on hematological disorders and blood substitute technologies.

Application

• Biochemical Research: Used as a standard or model compound in studies of protein structure-function relationships, ligand binding, and mutation effects.
• Diagnostic Development: Serves as a key component in the calibration and validation of diagnostic assays for detecting abnormal hemoglobin variants.
• Hematology Studies: Employed in research focused on understanding the pathophysiology of hemoglobin disorders such as thalassemias and other anemias.
• Pharmaceutical R&D: Investigated in the development of novel oxygen therapeutics and blood substitute products.
• Educational Reference: Used in academic settings for teaching advanced concepts in protein chemistry and molecular biology.
• Quality Control Material: Acts as a reference material in the quality control processes of clinical laboratories.

Basic Information

Product Name	Hemoglobin J Sardegna
CAS No.	100205-23-0
Molecular Formula	C2952H4664N812O832S8Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb J Sardegna; Hemoglobin variant J-Sardegna; α-50 His->Asp Hemoglobin; HBA1: c.151C>G (p.His50Asp); Hemoglobin alpha chain mutant; Oxyhemoglobin J Sardegna; Deoxyhemoglobin J Sardegna
EINECS	Contact for details

Quality Control

Our Hemoglobin J Sardegna is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and purity suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, electrophoresis, and spectrophotometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). For short-term use, aliquots may be stored at 2-8°C. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR / HPLC)	Conforms to standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Methemoglobin Content	≤ 5%
Oxygen Binding Capacity	Conforms to reference
Solubility	Clear solution in buffer
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.