Description

4-n-Maleimidophenyl Butanoic Acid is a heterobifunctional crosslinking agent featuring a maleimide group and a carboxylic acid group separated by a phenyl butanoic acid spacer. This compound is essential for creating stable, site-specific conjugations between thiol-containing molecules and amine-containing molecules under mild conditions. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and protein/peptide chemistry, enabling the precise engineering of therapeutic and diagnostic biomolecules.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: For site-specific labeling of cysteine residues with fluorescent dyes, enzymes, or other functional probes.
• Surface Functionalization: Used to modify gold nanoparticles, biosensor chips, or chromatographic resins with thiol-reactive groups for biomolecule immobilization.
• Polymer Conjugation: Enables the attachment of peptides or proteins to polymeric carriers for drug delivery systems.
• Diagnostic Reagent Synthesis: Employed in the development of immunoassay components and molecular imaging probes.
• Biomaterial Engineering: Facilitates the crosslinking of hydrogels or other biomaterials to incorporate bioactive peptides.

Basic Information

Product Name	4-n-Maleimidophenyl Butanoic Acid
CAS No.	100072-54-6
Molecular Formula	C14H13NO4
Molecular Weight	259.26 g/mol
Synonyms	4-(Maleimidophenyl)butyric Acid; 4-Maleimidophenylbutanoic Acid; 4-(3-Maleimidophenyl)butyric Acid; 4-(Maleimidophenyl)butanoic Acid; N-(4-Carboxybutyl)maleimide; 4-Maleimidobenzoic Acid Butyl Ester (related); MPB Acid; 4-MPB Acid; 4-(Maleimido)phenylbutyric Acid
EINECS	Contact for details

Quality Control

Our 4-n-Maleimidophenyl Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for identification, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF; slightly soluble in acetone

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.