Description

(R)-2-Hydroxy-2-Cyclohexylacetonitrile is a chiral, non-racemic building block of significant interest in fine chemical synthesis. Its value lies in the presence of both a nitrile and a hydroxyl group on a stereogenic center, enabling its use in the construction of complex, optically active molecules. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly those targeting the central nervous system or with complex cyclic structures.
• Agrochemical Synthesis: Used in the development of chiral pesticides and herbicides where specific stereochemistry is crucial for biological activity and environmental safety.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the development and testing of new asymmetric catalytic reactions.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high optical purity.
• Academic & Industrial R&D: A versatile building block for methodological studies in organic chemistry and for scaling up novel synthetic routes.

Basic Information

Product Name	(R)-2-Hydroxy-2-Cyclohexylacetonitrile
CAS No.	100007-62-3
Molecular Formula	C8H13NO
Molecular Weight	139.19 g/mol
Synonyms	(R)-2-Cyclohexyl-2-hydroxyacetonitrile; (R)-α-Hydroxycyclohexaneacetonitrile; (R)-Mandelonitrile, cyclohexyl-; (R)-Cyclohexylglycolonitrile; (2R)-2-Hydroxy-2-cyclohexylacetonitrile; (R)-Cyclohexanemethanol, α-hydroxy-, nitrile; (R)-2-Hydroxy-2-cyclohexylethanenitrile
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxy-2-Cyclohexylacetonitrile is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity determination by HPLC, to ensure compliance with customer specifications and industry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider the use of desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.