Description

Etoposide Glucuronide is a crucial metabolite of the chemotherapeutic agent etoposide, formed via glucuronidation. This compound is of significant value in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and the mechanisms of drug clearance. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in oncology drug development, bioanalytical method validation, and metabolite identification studies.

Application

• Pharmacokinetic and Metabolism Studies: Used as a reference standard to quantify etoposide glucuronide levels in biological matrices (plasma, urine) to understand the drug's metabolic fate and elimination pathways.
• Bioanalytical Method Development: Serves as a critical calibrant and quality control material for developing and validating sensitive HPLC-MS/MS or LC-UV assays.
• Drug-Drug Interaction (DDI) Research: Employed in in vitro studies to investigate the inhibition or induction of UDP-glucuronosyltransferase (UGT) enzymes, which are responsible for etoposide glucuronidation.
• Toxicology and Safety Assessment: Acts as a standard for characterizing metabolite profiles in preclinical and clinical safety studies.
• Chemical Reference Standard: Provides a high-purity benchmark for the identification and confirmation of etoposide metabolites in complex samples.
• Academic Research: Utilized in university and institutional labs for fundamental research on cancer therapeutics, drug resistance, and metabolic pathways.

Basic Information

Product Name	Etoposide Glucuronide
CAS No.	100007-55-4
Molecular Formula	C35H40O17
Molecular Weight	732.69 g/mol
Synonyms	Etoposide 4'-O-β-D-Glucuronide; Etoposide Glucuronide; 4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside], 4'-(β-D-Glucopyranosiduronic Acid); VP-16 Glucuronide; 4'-O-Glucuronyl Etoposide; Etoposide β-D-Glucuronide; Podophyllotoxin Glucuronide Derivative
EINECS	Contact for details

Quality Control

Our Etoposide Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.