Description

Acetamide, 2,2-Dichloro-n-(2-Hydroxy-1-(Hydroxymethyl)-2-(4-(Methylsul Fonyl)Phenyl)Ethyl)-, (S-(R*,R*))- is a high-purity, stereochemically defined synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is valued for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting specific biological pathways. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of novel small-molecule drugs.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), especially those with sulfonyl and amide functionalities.
• Medicinal Chemistry Research: Serves as a valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Fine Chemical Production: Utilized in the manufacture of other high-value, specialty chemicals requiring precise stereochemical control.

Basic Information

Product Name	Acetamide, 2,2-Dichloro-n-(2-Hydroxy-1-(Hydroxymethyl)-2-(4-(Methylsul Fonyl)Phenyl)Ethyl)-, (S-(R*,R*))-
CAS No.	19934-71-5
Molecular Formula	C12H15Cl2NO5S
Molecular Weight	364.22 g/mol
Synonyms	(2S)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-2-[(4-methylsulfonylphenyl)methyl]propanoic acid; 2,2-Dichloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl]acetamide; (S)-2-((2,2-Dichloroacetamido)(4-(methylsulfonyl)phenyl)methyl)-3-hydroxypropanoic acid; A key intermediate for specific sulfonamide-based APIs; Contact for specific IUPAC and trade name variants.
EINECS	Contact for details

Quality Control

Our Acetamide, 2,2-Dichloro-n-(2-Hydroxy-1-(Hydroxymethyl)-2-(4-(Methylsul Fonyl)Phenyl)Ethyl)-, (S-(R*,R*))- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP starting material applications. Certificates of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.