Description

5-Beta,14-β-Pregnan-20-One, 3-Beta,5,14,19,21-Pentahydroxy-, 3,19-D Iacetate 21-(Iodoacetate) CAS NO 19886-64-7 is a complex, multi-functional steroid derivative with a high degree of functionalization, making it a valuable advanced intermediate for pharmaceutical research and synthesis. This compound is critical for medicinal chemists developing novel therapeutic agents, particularly in the exploration of steroidal hormone analogs and receptor modulators. Its specific structure is primarily utilized in high-value pharmaceutical R&D for creating targeted molecular probes and potential active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel steroidal drugs and bioactive molecules.
• Medicinal Chemistry Research: Used as a precursor or a molecular scaffold for designing and testing new chemical entities (NCEs) with potential therapeutic effects.
• Biochemical Probe Development: The iodoacetate group makes it suitable for conjugation studies, potentially used to investigate protein interactions or as a labeling agent.
• Steroid Analog Synthesis: Essential for creating modified pregnane derivatives with altered biological activity for structure-activity relationship (SAR) studies.
• Reference Standard: Can be supplied as a high-purity compound for use as an analytical standard in quality control laboratories.
• Academic & Institutional Research: Used in university and institutional labs for advanced studies in organic synthesis and steroid chemistry.

Basic Information

Product Name	5-Beta,14-β-Pregnan-20-One, 3-Beta,5,14,19,21-Pentahydroxy-, 3,19-D Iacetate 21-(Iodoacetate)
CAS No.	19886-64-7
Molecular Formula	C29H41IO11
Molecular Weight	692.54 g/mol
Synonyms	21-(Iodoacetoxy)-3β,5,14β,19-tetrahydroxypregnan-20-one 3,19-diacetate; 3β,5,14β,19,21-Pentahydroxypregnan-20-one 3,19-Diacetate 21-Iodoacetate; 5β,14β-Pregnan-20-one, 3β,5,14,19,21-pentahydroxy-, 3,19-diacetate 21-(iodoacetate); 21-Iodoacetoxy Derivative of Tetrahydroxypregnanone Diacetate; Pregnane Steroid Iodoacetate Ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, NMR, and Mass Spectrometry for characterization. While typically supplied as a research-grade chemical, specifications can be aligned with GMP guidelines for advanced pre-clinical development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.