Description

Z-Gly-Gly-Gly-Onp is a protected tripeptide derivative, specifically the p-nitrophenyl ester of Z-protected triglycine. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioconjugates. The product offers high purity and reliable reactivity for demanding synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient coupling of the triglycine sequence.
• Solution-Phase Peptide Synthesis: Used in classical peptide bond formation strategies where a protected fragment is required.
• Bioconjugation: A reagent for attaching the Gly-Gly-Gly spacer to other molecules, proteins, or surfaces.
• Pharmaceutical Research: Intermediate in the synthesis of peptide-based drug candidates and diagnostic agents.
• Biochemical Tool Development: Used to create substrates for enzyme studies (e.g., proteases) or affinity tags.
• Material Science: Building block for creating peptide-functionalized polymers or biomaterials.

Basic Information

Item	Detail
Product Name	Z-Gly-Gly-Gly-Onp
CAS No.	19811-64-4
Molecular Formula	C₂₀H₂₀N₄O₈
Molecular Weight	444.40 g/mol
Synonyms	Z-GGG-ONp; N-Carbobenzoxy-glycyl-glycyl-glycine p-nitrophenyl ester; Benzyloxycarbonyl-Gly-Gly-Gly-ONp; Cbz-Gly-Gly-Gly-ONp; Nα-Cbz-triglycine p-nitrophenyl ester; (Benzyloxy)carbonyl-glycylglycylglycine 4-nitrophenyl ester; Z-Gly-Gly-Gly-OPhNO2; Glycine, N-[(benzyloxy)carbonyl]glycylglycyl-, 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-Gly-Onp is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is characterized by multiple analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the active ester. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.