Description

Methiothepin Maleate is a high-purity chemical compound of significant interest in advanced research and development. This compound serves as a potent and selective serotonin receptor antagonist, making it a critical tool for neuropharmacological studies and drug discovery programs. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies investigating central nervous system (CNS) pathways and receptor mechanisms.

Application

• Pharmacological Research: A key reference standard and active agent in studies targeting 5-HT (serotonin) receptors, particularly 5-HT1 and 5-HT2 families.
• Neuroscience & Neurochemistry: Used to elucidate the role of serotonin in various CNS functions, including mood, cognition, and sensory processing.
• Drug Discovery & Development: Employed as a biochemical tool in high-throughput screening (HTS) assays and in vitro models to identify and characterize new therapeutic candidates for psychiatric and neurological disorders.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for fundamental research into receptor pharmacology and signal transduction pathways.

Basic Information

Product Name	Methiothepin Maleate
CAS No.	19728-88-2
Molecular Formula	C₂₀H₂₆N₂O₂S₂ • C₄H₄O₄
Molecular Weight	502.62 g/mol
Synonyms	Methiothepin Maleate Salt; Methiothepin hydrogen maleate; 10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl 1-piperazinepropionate maleate; 1-(10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl)-4-(3-(4-morpholinyl)propyl)piperazine dimaleate; Ro 8-6837; Methitepin Maleate; Methiothepin dimaleate (common salt form).
EINECS	Contact for details

Quality Control

Our Methiothepin Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.