Description

n-Cbz-Dl-Histidine is a protected derivative of the amino acid histidine, where the carboxybenzyl (Cbz) group serves as a protective moiety for the amine functionality. This compound is a critical chiral building block and intermediate in the synthesis of complex peptides, pharmaceuticals, and bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, protected amino acids for advanced synthetic applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected histidine residue to prevent side reactions.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides and molecular probes for diagnostic and research purposes.
• Biochemical Research: Employed in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Fine Chemical Synthesis: A versatile building block for synthesizing non-natural amino acids, peptidomimetics, and other specialized organic compounds.

Basic Information

Product Name	n-Cbz-Dl-Histidine
CAS No.	19728-57-5
Molecular Formula	C14H17N3O4
Molecular Weight	291.31 g/mol
Synonyms	N-Carbobenzoxy-DL-histidine; Nα-Cbz-DL-histidine; Benzyl N-(DL-1H-imidazol-4-ylmethyl)carbamate; Carbobenzoxy-DL-histidine; Z-DL-His-OH; DL-Histidine, N-[(phenylmethoxy)carbonyl]-; NSC 3349; CBZ-DL-Histidine
EINECS	Contact for details

Quality Control

Our n-Cbz-Dl-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity (DL Ratio)	~50:50 (Racemic mixture)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.