Description

(S)-Benzyl 3-Hydroxy-1-(Methylamino)-1-Oxopropan-2-Ylcarbamate is a high-purity chiral building block and protected amino acid derivative of significant value in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of complex pharmaceuticals, particularly in the development of peptide-based drugs and enzyme inhibitors. Pharmaceutical R&D laboratories and fine chemical manufacturers need it to construct specific stereocenters with high enantiomeric purity, ensuring the efficacy and safety of final active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel peptide therapeutics and protease inhibitors.
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients (APIs) requiring specific (S)-configuration.
• Peptide Chemistry: Serves as a protected serine or threonine analogue for solid-phase and solution-phase peptide synthesis (SPPS).
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality.
• Bioconjugation: Potential use in creating linkers for antibody-drug conjugates (ADCs) or other bioconjugation strategies.
• Chemical Biology Probes: Useful for synthesizing labeled or modified amino acids to study biological processes and enzyme mechanisms.

Basic Information

Product Name	(S)-Benzyl 3-Hydroxy-1-(Methylamino)-1-Oxopropan-2-Ylcarbamate
CAS No.	19647-68-8
Molecular Formula	C13H18N2O5
Molecular Weight	282.29 g/mol
Synonyms	(S)-Benzyloxycarbonyl-3-hydroxy-N-methyl-L-alanine; (S)-Z-3-Hydroxy-N-methylalanine benzyl ester; (S)-N-Methyl-3-hydroxyalanine Z-derivative; (S)-Benzyl N-[(1S)-1-(Methylcarbamoyl)-2-hydroxyethyl]carbamate; (S)-Benzyl (1-Hydroxy-2-((methylamino)carbonyl)ethyl)carbamate; (S)-Cbz-3-Hydroxy-N-methyl-Ala-OH benzyl ester; (S)-3-Hydroxy-N-methylalanine, N-benzyloxycarbonyl-, benzyl ester
EINECS	Contact for details

Quality Control

Our (S)-Benzyl 3-Hydroxy-1-(Methylamino)-1-Oxopropan-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure compliance with research and development grade specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.