Description

8-Methoxy-10-(1-Methyl-4-Piperidyl)-10,11-Dihydrodibenzo(B,F)Thiepin Hydrogen Maleate is a high-purity, non-racemic pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial and research interest. Its value lies in its role as a key synthetic precursor for the development of novel therapeutic agents targeting the central nervous system. This compound is essential for pharmaceutical manufacturers and advanced research institutions engaged in the synthesis and development of neuroactive drugs, particularly within the fields of psychiatry and neurology.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the multi-step synthesis of complex neuroactive drug candidates.
• Active Pharmaceutical Ingredient (API) Development: Serves as the core active moiety for the formulation of investigational new drugs (INDs) in preclinical and clinical research.
• Neurological & Psychiatric Research: Used in biochemical and pharmacological studies to investigate receptor interactions and mechanisms of action for potential anxiolytic or antipsychotic agents.
• Reference Standard: Employed as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Process Chemistry & Scale-Up: Integral to process research and development (PR&D) for optimizing synthetic routes and ensuring robust, scalable manufacturing processes.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting cutting-edge medicinal chemistry and drug discovery programs.

Basic Information

Product Name	8-Methoxy-10-(1-Methyl-4-Piperidyl)-10,11-Dihydrodibenzo(B,F)Thiepin Hydrogen Maleate
CAS No.	19545-13-2
Molecular Formula	C26H29NO5S
Molecular Weight	467.58 g/mol
Synonyms	Zotepine Maleate; Zotepine Hydrogen Maleate; Lodopin (as maleate salt); 8-Methoxy-10-(1-methyl-4-piperidylidene)-10,11-dihydrodibenzo[b,f]thiepin Maleate; Nipolept Maleate; FR-1314 Maleate; (8-Methoxy-10-(1-methyl-4-piperidylidene)-10,11-dihydrodibenzo[b,f]thiepin) Maleate; Zotepinium Maleate
EINECS	Contact for details

Quality Control

Our production of 8-Methoxy-10-(1-Methyl-4-Piperidyl)-10,11-Dihydrodibenzo(B,F)Thiepin Hydrogen Maleate adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical applications. All materials are manufactured and tested in facilities that follow cGMP (current Good Manufacturing Practice) guidelines. Comprehensive analytical testing, including chiral purity verification, is performed, and a detailed Certificate of Analysis (COA) is provided with each shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5% (on anhydrous basis)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.