Description

n-Didesmethylpheniramine is a key pharmaceutical intermediate and metabolite of the antihistamine pheniramine. This compound is essential for research and development in the pharmaceutical industry, particularly for metabolic studies and the synthesis of advanced drug substances. It serves as a critical building block for analytical reference standards and is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs).

Application

• Primary reference standard for the analytical quantification of pheniramine and its metabolites in pharmacokinetic studies.
• Critical intermediate in the research-scale synthesis of novel antihistamine derivatives and related pharmaceutical compounds.
• Metabolite standard used in drug metabolism and pharmacokinetics (DMPK) research within preclinical and clinical development.
• Key material for impurity profiling and method validation in quality control laboratories for antihistamine APIs.
• Building block in organic synthesis for investigating structure-activity relationships (SAR) in medicinal chemistry programs.
• Component in the development of diagnostic assays and testing kits for forensic or clinical toxicology.

Basic Information

Product Name	n-Didesmethylpheniramine
CAS No.	19428-45-6
Molecular Formula	C16H20N2
Molecular Weight	240.35 g/mol
Synonyms	N-Desmethylpheniramine; Norpheniramine; Didesmethylpheniramine; 2-[2-(Dimethylamino)ethyl]-3-methylpyridine; 3-Methyl-2-[2-(dimethylamino)ethyl]pyridine; Pheniramine Impurity C; Pheniramine Metabolite; FEN-I
EINECS	Contact for details

Quality Control

Our n-Didesmethylpheniramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and confirming compliance with agreed specifications is provided with every shipment to ensure traceability and quality assurance for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.